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Nanotopographical Cues Tune the Therapeutic Potential of Extracellular Vesicles for the Treatment of Aged Skeletal Muscle Injuries

https://doi.org/10.1021/acsnano.3c02269

Wang, Kai; Frey, Nolan; Garcia, Andres; Man, Kun; Yang, Yong; Gualerzi, Alice; Clemens, Zachary J; Bedoni, Marzia; LeDuc, Philip R; Ambrosio, Fabrisia (October 2023, ACS Nano)

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Microfluidics for understanding model organisms

https://doi.org/10.1038/s41467-022-30814-6

Frey, Nolan; Sönmez, Utku M.; Minden, Jonathan; LeDuc, Philip (December 2022, Nature Communications)

Abstract New microfluidic systems for whole organism analysis and experimentation are catalyzing biological breakthroughs across many fields, from human health to fundamental biology principles. This perspective discusses recent microfluidic tools to study intact model organisms to demonstrate the tremendous potential for these integrated approaches now and into the future. We describe these microsystems' technical features and highlight the unique advantages for precise manipulation in areas including immobilization, automated alignment, sorting, sensory, mechanical and chemical stimulation, and genetic and thermal perturbation. Our aim is to familiarize technologically focused researchers with microfluidics applications in biology research, while providing biologists an entrée to advanced microengineering techniques for model organisms.
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Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System

https://doi.org/10.3791/64281

Sönmez, Utku M; Frey, Nolan; Minden, Jonathan S; LeDuc, Philip R (January 2022, Journal of Visualized Experiments)

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Reversible Click Chemistry Tag for Universal Proteome Sample Preparation for Top-Down and Bottom-Up Analysis

https://doi.org/10.1021/acs.jproteome.1c00443

Biedka, Stephanie; Schmidt, Brigitte F.; Frey, Nolan M.; Boothman, Sarah M.; Minden, Jonathan S.; Wilson, Amber Lee (September 2021, Journal of Proteome Research)

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